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The R.O.C.S. products are developed by WDS Laboratory. The claimed effects of the products have been proven in clinical studies and laboratory trials. Efficacy and safety of the R.O.C.S. products are confirmed by independent studies and are reflected in numerous scientific publications. Please select a topic and read the article.

Kirillova E. V., et al. Microbiological monitoring of the dental biofilm condition during application of chlorhexidine and xylitol in the complex medical treatment of early childhood caries

Children Dentistry and Prophylaxis, 2009, 2, pp. 86-94


High prevalence of Early Childhood Caries (ECC) makes speak of the necessity of the medicinal-and-prophylactic means application that will influence on the pathogenic micro-flora, a major factor of etiopathogenesis of the described disease. While conducting present research work, the comparative data relating to antibacterial efficiency of the preparations containing xylitol and chlorhexidine were obtained. Impact of these preparations upon the structure of microbiocenosis of the dental biofilm was also studied.


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Zheleznyy, P.A., et al. Application of the Remineralizing Therapy During At-Home Vital Teeth Whitening

“Clinical Dentistry”, №1 2008, pp. 28-31


In the course of the last decade one can observe an increase in the aesthetic requirements of patients caused by various reasons including the impact of foreign mass media promoting natural beauty of healthy teeth.

The idea of tooth whitening attracts many patients. When they come to a dentist’s room for medical advice regarding this procedure, in most cases they question about safety. Enamel hyperesthesia (14—78% of the cases) and irritation of soft tissues (that is why it is recommended to thoroughly isolate gums from contact with the peroxide gel) are the most wide-spread side effects of tooth whitening. This research examines the effect of application of R.O.C.s. Medical Minerals gel in the patients who underwent the procedure of tooth whitening. The following characteristics were under control in the course of one year:

1. Tooth colour

2. Hyperesthesia presence

3. Dental caries intensity according to DMF index (decayed, missing, filled teeth)

4. Calcium content in the oral cavity fluid

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Kunin, A.A., Kravchuk, P.S., Belenova, I. A. Comparative Analysis of the Hard Tooth Tissues after Using a Toothpaste Containing Fluorine and R.O.C.S. Toothpaste Containing Bromelaine for Oral Cavity Hygienic Care

“Clinical Dentistry”, №1 2009, pp. 40-42

Therapeutic dentistry department of VSMA named after N.N. Burdenko



The most effective influence upon the composition of the dental plaque can be made by the toothpastes having a broad spectrum anti-infective agent among its ingredients, for instance, tryklozan, as due to the action of an anti-bacterial additive such toothpastes inhibit the tooth plaque from formation. One can rarely find hygienic preparations that make an antiplaque effect due to the presence of nature ingredients in their composition. On the .market among such toothpastes the most well-known ones are R.O.C.S. pastes, which include bromelaine, a protein-degrading enzyme, and a high concentration of xylitol.

Thus, the purpose of this investigation is to compare the influence of the toothpaste based upon tryklozan, a broad spectrum anti-infective agent, that also has sodium fluoride ([F−]=0,145%) in its composition, with the effect of a paste comprising xylitol, bromelaine, calcium glycerophosphate and magnesium chloride upon the dental plaque formation velocity and cariogenic potential of the dental deposit.

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Matelo, S.K., Kupets, T.V., Dental Fluorosis – A Fast Growing Problem of the Modern Aesthetic Dentistry

Prophylaxis Today, September 2008, pp. 10-12


Dental fluorosis is attributed to the group of non-carious diseases of type one, in other words to a group of disorders developing prior to the tooth eruption. Dental fluorosis is produced by the ingestion of excessive amounts of fluoride by a child organism. Fluorosis of the mature dental enamel of a human being is described as the subsurface hypermineralization with porosity, which increases relatively to the severity rate of fluorosis. Agencies and organizations dealing with the population health protection attached different degrees of importance to the problem of dental fluorosis at different times. For instance, the USA Agency for environment protection considers dental fluorosis not as a disease but as a cosmetic defect. The World Health Organization (WHO) attributes dental fluorosis to the diseases which affect millions of people on the whole globe.


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Sarap L.R. et al, Medicinal-and-prophylactic effectiveness of the natural extract based toothpastes among patients suffering from inflammatory parodentium diseases.

Department of child dentistry of the Altai state medical university


Parodentium diseases are considered to be not only a stomatological, but also a general medical and even social problem. Its full solution still remains a principal direction of the modern dentistry development as these diseases are the most widespread ones among the population of the globe after caries. According to evidence received during the epidemiologic stomatological examination of the population in Russia, conducted in 1999 under the aegis of WHO, the prevalence of the parodentium diseases in this country is high. [1]. In the 35-44 age group the number of individuals with the parodentium disease symptoms of various degree of intensity constitute more than 86% .


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Fyodorov Y.A., Fluorine: Pros and Cons

“Prophylaxis Today”, March 2007, pp. 4-6


Fluorine plays a great role in the prevention of dental diseases. Most dentists consider fluorides as the most effective means of decreasing of risk of caries. But is it true? We can notice that fluoride-containing toothpastes have been prevailing during the last decade (up to 95%). But has it lead to decrease of caries prevalence? According to epidemiologic studies, in the regions where water is saturated enough by fluorine (0,5 – 1 mg/l), the indices of caries are lower, but only in children and not in adults.


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Afinogenov G.E . et al. Antiadhesive Action of Dentifrices

“Clinical Dentistry”, №3 2006, pp. 55-57


During the clinical studies of the toothpaste ROCS the investigators obtained data about the significant improvement of oral hygiene. The inhibition of dental plaque accumulation was noticed both by investigators and by study subjects. These data urged us to conduct additional research to assess the influence of the proteolytic enzyme bromeline (one of the key components of the patented formula) on the antiadhesive action of the toothpaste ROCS.


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L.R. Sarap et al. Prophylactic Care in Patients with Periodontal Disease

“Clinical Dentistry” № 3, 2005


This article contains the results of the clinical assessment of efficacy of dentifrice ROCS for adults1 in patients with the chronicle catarrhal gingivitis and mild periodontitis. There was significant anti-inflammatory effect in all the study participants (n=26) after the first week of usage. After 4 weeks of dentifrice usage the decrease of inflammation reached 92,94%. Especially appealing is the fact that high anti-inflammatory result was reached without antibacterial agents. The formula of dentifrice ROCS includes the active complex MINERALIN created on the basis of natural components.


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L.R. Sarap et al. Use of the Remineralizing Gel R.O.C.S. Medical Minerals in Dental Practice

Department of children’s dentistry, State medical university of Altai, DRC Group, Moscow


Prevention and treatment of caries and non-carious lesions by means of remineralization has been studied for many decades and has a good scientific basis. The theoretical ground for remineralization as a measure of caries prevention and treatment is based on the retention of protein matrix in dental enamel at early stage of caries (white spot) and on the possibility of its remineralization.

Taking into consideration the constant growth of caries intensity as well as growing prevalence of multiple non-carious diseases (more than 80%) and hypersensitivity, the remineralizing therapy in dental practice is of current importance.


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A.A.Kunin. Comparative Analysis of Effect of Different Toothpastes on the Caries-Resistance of Dental Enamel

“Clinical Dentistry” № 4, 2005


This study aimed to compare the influence of toothpaste containing sodium fluoride (concentration of fluoride ions 1500 ppm) and a toothpaste without fluoride, containing calcium, phosphate and magnesium, on the structural and functional caries-resistance of dental enamel and remineralizing potential of oral fluid.


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Medical efficacy of the R.O.C.S. toothpastes in improving oral health of school children

2011, 1 Pediatric Dentistry And Prevention


Two-years school-based programme of the supervised toothbrushing of 6-7-years old school children with the use of the R.O.C.S. (Remineralizing Oral Care System) toothpastes had shown very effective results in reducing OHI-S by 53-57%, GI by 57-73% and 2-year DMFT reducing by 29-32%. The remineralizing F-free, AmF 500 ppm. and NaF 1000 ppm. toothpastes were equally effective in improving oral health of schoolchildren.


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